A. Ribes et al., PEARSON SYNDROME - ALTERED TRICARBOXYLIC-ACID AND UREA-CYCLE METABOLITES, ADRENAL INSUFFICIENCY AND CORNEAL OPACITIES, Journal of inherited metabolic disease, 16(3), 1993, pp. 537-540
Pearson syndrome (McKusick 260560) is a multisystem disorder of mitoch
ondrial energy metabolism. Fatal outcome is widely reported and is usu
ally related to liver failure (Rotig et al 1990). We describe the case
of a 3-year-old boy with Pearson syndrome but with normal pancreatic,
hepatic and renal function. Furthermore, he presents bilateral cornea
l opacity and hypoaldosteronism. In addition, altered Krebs' and urea-
cycle metabolites were found.