A severe, acutely evolving peripheral gangrene of unknown etiology has
been reported sporadically from different parts of Africa. This case
report describes such a case of fulminant gangrene of the extremities
following a febrile diarrheal illness associated with abdominal pain,
polyarthropathy, and altered hemostatic function in a black adolescent
male. A model of autoimmune causation for this uncommon clinical synd
rome is proposed with guidelines for therapy.