A MICROSATELLITE-BASED INDEX MAP OF HUMAN CHROMOSOME-11

We have constructed a continuous index map of 25 microsatellite marker s on human chromosome 11. The markers have been typed in 40 CEPH famil ies, have heterozygosities of 69% or higher and can be typed by PCR. T he odds against inversion of adjacent marker loci order are at least 1 0(5):1. The sex average map covers a total of 162 cM with no gap excee ding 15 cM. Total lengths for female and male maps are 205 and 123 cM, respectively. By use of a hybrid cell panel or by in situ hybridizati on, 16 of the markers have also been mapped cytogenetically, providing a good correlation of the index map with the cytogenetic map. The map will facilitate high resolution mapping of additional polymorphic loc i and of disease genes on chromosome 11.