This study investigated the prevalence of comorbid panic disorder in p
atients with recurrent wintertime episodes of major depression. The su
bjects were 38 patients (10 male and 28 female) who met the DSM-III-R
criteria for major depression with a seasonal pattern (wintertime depr
ession). Diagnoses of panic disorder were made according to the DSM-II
I-R criteria. Nine (23.7%) of the subjects (four women and five men) m
et the criteria for panic disorder. Their panic attacks and depressive
symptoms bad simultaneous onset in the fall or winter and remitted sp
ontaneously in the spring. Patients with winter depression appear to b
e at high risk for simultaneous panic disorder, consistent with result
s from studies in which season of illness was not considered.