EFFECT OF SECRETIN ON VAGAL STIMULATION-EVOKED EXOCRINE PANCREATIC-SECRETION IN THE RAT

Authors
WISDOM D SINGH J CAMELLO PJ PARIENTE JA SALIDO GM
Citation
D. Wisdom et al., EFFECT OF SECRETIN ON VAGAL STIMULATION-EVOKED EXOCRINE PANCREATIC-SECRETION IN THE RAT, Revista Espanola de Fisiologia, 49(1), 1993, pp. 31-35
Citations number
23
Categorie Soggetti
Physiology
Journal title
Revista Espanola de Fisiologia → ACNP
ISSN journal
00349402
Volume
49
Issue
1
Year of publication
1993
Pages
31 - 35
Database
ISI
SICI code
0034-9402(1993)49:1<31:EOSOVS>2.0.ZU;2-6
Abstract
The effect of secretin on nerve-mediated pancreatic juice secretion in the anaesthetized rat has been studied. Vagotomy caused a significant reduction in the rate of pancreatic juice flow, total protein output and amylase secretion being compared to control values prior to vagoto my. Both secretin (intravenous infusion 10(-10) mol/kg body weight/h) and electrical stimulation of the vagus nerves (4 V, 2 ms, 20 Hz) caus ed marked increases in flow, total protein output and amylase output. Pretreatment of rats with atropine (0.1 mg/kg body weight) abolished t he electrical stimulation-evoked secretion. However, simultaneous intr avenous infusion of secretin and electrical stimulation did not yield either a clear additive response or a potentiation of secretory respon ses.