ITRACONAZOLE PLASMA AND VAGINAL MUCOSAL LEVELS IN PATIENTS WITH CHRONIC VAGINAL CANDIDOSIS TREATED WITH ITRACONAZOLE 200MG ONCE-DAILY FOR 3CONSECUTIVE DAYS

20 nonpregnant patients with chronic vaginal candidosis were divided r andomly into 5 groups of 4 Patients. They all received itraconazole 20 0mg once daily for 3 consecutive days. A blood sample and vaginal biop sy were obtained 1 hour after each administration as well as 25 and 50 hours after the last drug intake. The results show that the itraconaz ole levels in the vaginal mucosa are comparable with the corresponding blood levels, but that after the end of treatment, drug levels in the vagina remain elevated for much longer than the corresponding blood l evels. These data suggest that a regimen of itraconazole 200mg once da ily for 3 days results in therapeutic tissue levels at the site of inf ection for more than 5 days.