M. Farivar et al., FACTORIAL DESIGN-BASED OPTIMIZATION OF THE FORMULATION OF ISOSORBIDE-5-MONONITRATE MICROCAPSULES, Journal of microencapsulation, 10(3), 1993, pp. 309-317
Citations number
NO
Categorie Soggetti
Pharmacology & Pharmacy","Chemistry Applied","Engineering, Chemical
Sustained action Isosorbide-5-mononitrate (IS-5-MN) microcapsules are
prepared in order to overcome the tolerance developed in conventional
preparations and to increase patient compliance. For this purpose, fac
torial design experiments are performed and microcapsules of IS-5-MN a
re formulated by the organic phase separation method using ethylcellul
ose with two different viscosities (10 and 45 cp) as coating material,
The independent variables in the 2 x 3 x 3 factorial design are core:
wall ratio, particle size and pH of the medium. The dependent variabl
e, t50 per cent is investigated by the second-order polynomial equatio
n to establish the correlation between independent variables. By using
the calculated equations, the response-surface graphs, from which var
ious levels of independent variables could be predicted, are obtained.
The in vitro release profiles of the formulated microcapsules and the
commercially available preparations are obtained by using the rotatin
g basket method. In vitro release is evaluated by zero-order, first-or
der, Hixson-Crowell and Higuchi release kinetics. The t50 per cent val
ues obtained from the Higuchi equation are used as response in the 2 x
3 x 3 factorial design experiments.