DECREASE IN THE PLACENTAL-TRANSFER OF CHLORAMPHENICOL WHEN ADMINISTERED IN ALBUMIN MICROSPHERES INTO RATS

Authors
ONUR MA VURAL I KAS HS HINCAL AA COSKUN T KANRA G TUMER A
Citation
Ma. Onur et al., DECREASE IN THE PLACENTAL-TRANSFER OF CHLORAMPHENICOL WHEN ADMINISTERED IN ALBUMIN MICROSPHERES INTO RATS, Journal of microencapsulation, 10(3), 1993, pp. 367-374
Citations number
NO
Categorie Soggetti
Pharmacology & Pharmacy","Chemistry Applied","Engineering, Chemical
Journal title
Journal of microencapsulation → ACNP
ISSN journal
02652048
Volume
10
Issue
3
Year of publication
1993
Pages
367 - 374
Database
ISI
SICI code
0265-2048(1993)10:3<367:DITPOC>2.0.ZU;2-Y
Abstract
Chloramphenicol is an antibiotic which can pass across the human place nta and has teratogenic effects in the foetus. When this antibiotic is entrapped in albumin microspheres and administered to pregnant rats i ntravenously its placental transport is significantly lowered when com pared with that of free drug. Drug modifications such as entrapment ar e suggested as an alternative way to prevent harmful effects of drugs in case of consumption during pregnancy.