Iv. Isupov et al., ROLE OF NEURAMINIDASE IN DERMATONECROTIC LESIONS DEVELOPING AFTER THEINJECTION OF SOME VIBRIO-CHOLERAE ANTIGENS, Zurnal mikrobiologii, epidemiologii i immunobiologii, (1), 1993, pp. 7-11
The intradermal injection of the purified preparation of neuraminidase
(0.5 specific human doses or 1 NU) and significant doses (4-12-18 spe
cific human doses) of choleragen toxoid containing this enzyme to rabb
its has been shown to produce a dermonecrotic effect in the animals.