PROTECTIVE ACTIVITY OF ORAL MULTICOMPONEN T VACCINE PREPARED FROM THEANTIGENS OF OPPORTUNISTIC MICROORGANISMS

Multicomponent vaccine BPI-4, prepared from Streptococcus, Klebsiella, Proteus and Escherichia coli antigens, was tested for protective acti vity by oral administration to mice with experimental Klebsiella, Prot eus and S. pneumoniae infections. Vaccine BPI-4, when introduced orall y (in 2-3 administrations of 2 mg), found to produce a protective effe ctiveness index was equal to 5.7 and 4.3). With respect to P. vulgaris , the effectiveness index was 2.7 (immunization was made in two oral a dministrations of 2 mg); in pneumococcal infection preliminary oral im munization with vaccine BPI-4 in two administrations in a dose of 2-4 mg produced high protective effect. Thus, immunization with vaccine BP I-4, introduced orally in comparatively small doses, proved to be effe ctive in animal models used in the experiment.