DETERMINATION OF THE ANTIGENIC DETERMINAN T OF PREVENTIVE MONOCLONAL-ANTIBODIES, SPECIFIC TO FRANCISELLA-TULARENSIS LIPOPOLYSACCHARIDE

Authors
KHLEBNIKOV VS GOLOVLEV IR TOKHTAMYSHEVA NV AVERIN SF KULEVATSKY DP GRECHKO GK AVERINA AA VETCHININ SS
Citation
Vs. Khlebnikov et al., DETERMINATION OF THE ANTIGENIC DETERMINAN T OF PREVENTIVE MONOCLONAL-ANTIBODIES, SPECIFIC TO FRANCISELLA-TULARENSIS LIPOPOLYSACCHARIDE, Zurnal mikrobiologii, epidemiologii i immunobiologii, (1), 1993, pp. 83-88
Citations number
14
Categorie Soggetti
Microbiology,Immunology,"Public, Environmental & Occupation Heath
Journal title
Zurnal mikrobiologii, epidemiologii i immunobiologii → ACNP
ISSN journal
03729311
Issue
1
Year of publication
1993
Pages
83 - 88
Database
ISI
SICI code
0372-9311(1993):1<83:DOTADT>2.0.ZU;2-W
Abstract
F. tularensis lipopolysaccharide (LPS) was studied with the use of mon oclonal antibodies (McAb) having protective properties. The binding si te of these McAb (IgG2a) is localized on the O-chain of LPS. In contra st to LPS isolated from vaccine strain 15, LPS isolated from F. tulare nsis cells in the R-form has no O-chains and does not interact with Mc Ab.