SYNTHESIS OF CHIRAL 5-SUBSTITUTED 2-PYRROLIDINONES - AN UNUSUAL ONE-STEP TRANSFORMATION

Authors
WEI ZY KNAUS EE
Citation
Zy. Wei et Ee. Knaus, SYNTHESIS OF CHIRAL 5-SUBSTITUTED 2-PYRROLIDINONES - AN UNUSUAL ONE-STEP TRANSFORMATION, Tetrahedron letters, 34(28), 1993, pp. 4439-4442
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
28
Year of publication
1993
Pages
4439 - 4442
Database
ISI
SICI code
0040-4039(1993)34:28<4439:SOC52->2.0.ZU;2-6
Abstract
An efficient methodology for the enantioselective synthesis of gamma-l actams, using a one-pot reaction of chiral N-alkoxycarbonyl gamma-amin o alpha,beta-unsaturated carboxylates with methanol, afforded the targ et chiral compounds in high chemical yield (87-95%) and optical purity (96-99% ee).