AN EFFICIENT ASYMMETRIC-SYNTHESIS OF THE 4 STEREOISOMERS OF 3-HYDROXYLEUCINE

Authors
SUNAZUKA T NAGAMITSU T TANAKA H OMURA S
Citation
T. Sunazuka et al., AN EFFICIENT ASYMMETRIC-SYNTHESIS OF THE 4 STEREOISOMERS OF 3-HYDROXYLEUCINE, Tetrahedron letters, 34(28), 1993, pp. 4447-4448
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
28
Year of publication
1993
Pages
4447 - 4448
Database
ISI
SICI code
0040-4039(1993)34:28<4447:AEAOT4>2.0.ZU;2-U
Abstract
The four stereoisomers of 3-hydroxyleucine have been prepared in high overall yield and enantiomeric purity. Key steps include Sharpless asy mmetric epoxidation, benzyl isocyanate-induced epoxide opening, and ep imerization of an intermediate oxazolidinone ester.