METAL CHELATING AMINO-ACIDS IN THE DESIGN OF PEPTIDES AND PROTEINS - SYNTHESIS OF N-ALPHA-FMOC BU(T) PROTECTED AMINO-ACIDS INCORPORATING AMINODIACETIC ACID MOIETY

Authors
KAZMIERSKI WM
Citation
Wm. Kazmierski, METAL CHELATING AMINO-ACIDS IN THE DESIGN OF PEPTIDES AND PROTEINS - SYNTHESIS OF N-ALPHA-FMOC BU(T) PROTECTED AMINO-ACIDS INCORPORATING AMINODIACETIC ACID MOIETY, Tetrahedron letters, 34(28), 1993, pp. 4493-4496
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
28
Year of publication
1993
Pages
4493 - 4496
Database
ISI
SICI code
0040-4039(1993)34:28<4493:MCAITD>2.0.ZU;2-4
Abstract
The synthesis of Fmoc/Bu(t) protected amino acid chelators 14, 15, 16 and 24 is described. With respect to their Boc/Bzl derivatives, the ti tle compounds offer synthetic advantage: Peptide Ac-Ada(1)-Ala3-Ada(1) -Ala4-Glu-Lys-NH2 was assembled by Solid PPS in 74.2% yield.