METAL CHELATING AMINO-ACIDS IN THE DESIGN OF PEPTIDES AND PROTEINS - SYNTHESIS OF N-ALPHA-FMOC BU(T) PROTECTED AMINO-ACIDS INCORPORATING AMINODIACETIC ACID MOIETY
Wm. Kazmierski, METAL CHELATING AMINO-ACIDS IN THE DESIGN OF PEPTIDES AND PROTEINS - SYNTHESIS OF N-ALPHA-FMOC BU(T) PROTECTED AMINO-ACIDS INCORPORATING AMINODIACETIC ACID MOIETY, Tetrahedron letters, 34(28), 1993, pp. 4493-4496
The synthesis of Fmoc/Bu(t) protected amino acid chelators 14, 15, 16
and 24 is described. With respect to their Boc/Bzl derivatives, the ti
tle compounds offer synthetic advantage: Peptide Ac-Ada(1)-Ala3-Ada(1)
-Ala4-Glu-Lys-NH2 was assembled by Solid PPS in 74.2% yield.