DEFICIENCIES IN PHYSIOLOGICAL COAGULATION INHIBITORS IN CHILDREN WITHVEIN-THROMBOSIS OF THE LOWER-LIMBS - A PROSPECTIVE-STUDY OF 6 CASES

Six patients aged 3 to 14 years with lower limb vein thrombosis were i ncluded in a prospective study of deficiencies in physiological coagul ation inhibitors. The. laboratory evaluation included standard hemosta sis tests, tests for circulating anticoagulants, immunological and fun ctional assays of protein C, protein S, and antithrombin III, and a st udy of fibrinolysis. A qualitative protein S deficiency with decreased fibrinolysis and protein C deficiency were found. The family study de tected asymptomatic heterozygotes in both families investigated. No an tithrombin III deficiency or circulating anticoagulants were found.