INHIBITION OF LYMPHOCYTE-INDUCED ANGIOGENESIS BY COPPER AND TNF

T-lymphocytes from tumor-bearing mice induced a strong neovascular res ponse when inoculated i.d. in syngeneic animals (SLIA: syngeneic lymph ocyte-induced angiogenesis). In this report. recombinant human tumor n ecrosis factor (rHuTNF) inhibited this angiogenic response. The lack o f SLIA was also observed under copper supply diet. As SLIA involves th e release of lymphokines from activated T-cells, our results would sug gest that the suppression of angiogenesis could be also ascribed to an effect of TNF and copper on the immune system.