Recent formulations of two broad personality styles, a dependent (anac
litic) and a self-critical (introjective) personality style (Blatt, 19
74, 1990; Blatt & Shichman, 1983), provide a theoretical model for int
egrating a diversity of findings linking personality factors to the on
set and clinical course of immunological and cardiovascular disease. T
he model of a dependent (anaclitic) personality style appears to provi
de a structure for integrating, within an independently established co
nceptual system, the use of repressive defenses, feelings of helplessn
ess, emotional lability, and preoccupations with interpersonal relatio
nships, which have each been found to be predictive factors in neoplas
tic disease. The model of a self-critical (introjective) personality s
tyle appears to provide a conceptual structure for integrating the div
erse findings indicating that personality factors Of social isolation
and mistrust, along with preoccupations with anger, autonomy, assertio
n, control, and self-worth (e.g., failure and achievement), are import
ant in cardiovascular disease. The formulation of these two personalit
y styles also contributes to understanding the role of personality fac
tors in vulnerability to these two types of disease by suggesting that
dependent individuals are more responsive to interpersonal disruption
and generally respond to this type of stresser with passivity and res
ignation, while self-critical individuals are primarily responsive to
loss of self-control and self-worth, and generally react to these stre
ssors with heightened behavioral and autonomic arousal. These formulat
ions also suggest that these personality styles are linked to clinical
course because they make it difficult for individuals to alter behavi
or and life-style habits in ways that could facilitate obtaining care
from medical staff and assistance from social support systems to cope
with the impact of the disease process. Furthermore, these formulation
s have implications for considering different types of psychological i
nterventions as part of comprehensive treatment programs; they raise q
uestions about the role of depression in neoplastic and cardiovascular
disease; and they indicate directions that should be explored in futu
re research on the role of personality factors in physical health and
illness.