Homeobox (HOX) genes are a gene family that encode information critica
l for the normal embryologic development of many different organisms,
including vertebrates. HOX genes encode transcriptional regulatory fac
tors that bind to multiple different genes and thereby determine the d
evelopmental fate of a cell. The role of HOX genes in the development
of skin is undetermined but, based on information from other organisms
and recent experimental data from skin models, it is likely that this
class of genes is important for the normal development of skin adnexa
e, pigmentary system, and stratified epidermis during embryogenesis. T
he purpose of this review is to briefly summarize what is known about
HOX genes and to familiarize the reader with recent insights into how
HOX genes may function in skin development.