Pulmonary edema is an uncommon but serious complication associated wit
h major resection of the lung, usually after pneumonectomy. The pathop
hysiology of this condition is not completely understood, but recent e
xperimental and clinical data suggest that this condition results from
a combination of increased filtration gradient across the pulmonary m
icrocirculation together with hyperpermeability. Overzealous periopera
tive infusions of fluid have been implicated in clinical cases. We pre
sent the reports of 2 patients with postpneumonectomy pulmonary edema
we recently encountered and a review of the literature to provide diag
nostic and therapeutic guidelines in dealing with this serious complic
ation.