CISPLATIN NEPHROTOXICITY - EARLY FUNCTION AL GLOMERULAR AND TUBULAR CHANGES

In order to assess those parameters that were the most accurate and ea rly predictors of nephrotoxic changes induced by cisplatin treatment, we have studied a group of patientes (n = 25) with ovarian adenocarcin oma who underwent therapy with this drug. They received 12 courses of 80 mg/m2 every four weeks. At the end of the treatment, we found that there was a statistically significant increase in plasma creatinine va lues with a 10 % decrease in creatinine clearance measurement. Urinary excretion of calcium fell in an early and progressive fashion. We hav e not found evidence of renal tubular acidosis. We conclude that, in o rder to evaluate the cisplatin nephrotoxicity, it is useful to monitor the plasma creatinine values and creatinine clearance, and that hypoc alciuria is the most constant and earliest sign of renal tubular disfu nction as an expression of cisplatin toxicity. This picture resembles that of adult Bartter's syndrome of Gitelman's syndrome.