CORRELATIONS OF PERITONEAL INTERLEUKIN-6, SERUM BETA-2-MICROGLOBULIN AND URINARY BETA-2-MICROGLOBULIN AFTER ELECTIVE ABDOMINAL-SURGERY

Postoperative peritoneal interleukin-6 (P-IL-6), serum beta-2 microglo bulin (SBMG) and urinary beta-2 microglobulin (UBMG) concentrations we re examined in 33 patients who underwent various types of abdominal su rgery. Similar time-dependent changes in SBMG and UBMG were observed i n five other patients who underwent abdominal surgery. SBMG decreased the first day after the operation (IPOD), then increased and reached t he preoperative level by the third day after the operation (3POD). UBM G started to increase IPOD, reached the maximum 3POD, then decreased. The IPOD SBMG concentration was significantly correlated with P-IL-6, and 3POD UBMG was also significantly correlated with P-IL-6. These fin dings indicate that serum and urinary beta-2 microglobulin concentrati ons are closely correlated with P-IL-6.