EFFECT OF LONG-TERM EXPOSURE TO LEAD ON TESTIS AND EPIDIDYMIS IN RATS

The relation was studied between the morphology of testes and epididym ides on the one hand, and the lead content in these organs on the othe r. The testes of rats, which for the time of 5 spermatogeneses (9 mont hs) were drinking 1% lead acetate(II), displayed all generations and l ayers of spermatogenic cells at respective stages of the seminiferous epithelium cycle. The lead content in testes of the animals did not di ffer significantly from the value of this element in gonads of control rats. The epididymal cells also failed to show morphological changes however, in all epididymal zones there were fewer spermatozoa than in the corresponding zones in control rats. Many spermatozoa revealed abn ormal reactions of oxidoreductive enzymes in the midpiece. There were also local defects in tetrazolium salt reduction and segmental or tota l lack of formazan deposits in the mitochondrial sheath. The lead cont ent in epididymes of these animals was significantly higher than in ep ididymides of control rats. The obtained results of the studies highli ght the possibility for lead to accumulate in epididymis, and for lead compounds to damage spermatozoa in this organ.