IN-VITRO ACTIVITY OF CEFODIZIME (HR-221) IN COMBINATION WITH BETA-LACTAMASE INHIBITORS

Authors
SEGATORE B PERILLI M FRANCESCHINI N SETACCI D ORATORE A AMICOSANTE G
Citation
B. Segatore et al., IN-VITRO ACTIVITY OF CEFODIZIME (HR-221) IN COMBINATION WITH BETA-LACTAMASE INHIBITORS, Journal of chemotherapy, 5(3), 1993, pp. 147-150
Citations number
NO
Categorie Soggetti
Oncology,"Pharmacology & Pharmacy
Journal title
Journal of chemotherapy → ACNP
ISSN journal
1120009X
Volume
5
Issue
3
Year of publication
1993
Pages
147 - 150
Database
ISI
SICI code
1120-009X(1993)5:3<147:IAOC(I>2.0.ZU;2-E
Abstract
Cefodizime (formerly HR221) was tested either for in vitro microbiolog ical activity or for its stability to beta-lactamases in the presence of two beta-lactamase inhibitors (clavulanic acid, tazobactam). Cefodi zime was a poor substrate of class C enzymes but hyperproducer strains were generally resistant with or without a beta-lactamase inhibitor u sed in combination. On the contrary, class A enzymes were able to hydr olyze cefodizime. However, strains expressing class A beta-lactamase w ere susceptible to cefodizime in combination with clavulanic acid.