IN-VITRO ANTIMYCOBACTERIAL ACTIVITY OF NEW SYNTHETIC AMIDRAZONE DERIVATIVES

After preliminary in vitro screening of 15 newly synthesized compounds belonging to the chemical class of N1-(aryliden)-4-pyridinecarboxyami drazones against Mycobacterium tuberculosis reference strain H37 Rv, w e determined the minimum inhibitory concentrations (MICs) of the six m ost promising chemicals against different species of Mycobacterium and different strains of M. tuberculosis. The agar dilution method was em ployed against M. gordonae, M. bovis, M. kansasi, M. avium, M. fortuit um and on eighteen different strains of M. tuberculosis, isolated from human bronchial aspirates. The results obtained confirmed that the ne wly synthesized chemicals possessed a very interesting antitubercular activity, their MICs ranging from 4 mug/ml to 16 mug/ml.