HETEROSYNAPTIC LONG-TERM DEPRESSION IN THE HIPPOCAMPUS

Authors
SCANZIANI M NICOLL RA MALENKA RC
Citation
M. Scanziani et al., HETEROSYNAPTIC LONG-TERM DEPRESSION IN THE HIPPOCAMPUS, J PHYSL-PAR, 90(3-4), 1996, pp. 165-166
Citations number
3
Categorie Soggetti
Physiology,Neurosciences
Journal title
JOURNAL OF PHYSIOLOGY-PARIS
ISSN journal
09284257 → ACNP
Volume
90
Issue
3-4
Year of publication
1996
Pages
165 - 166
Database
ISI
SICI code
0928-4257(1996)90:3-4<165:HLDITH>2.0.ZU;2-9
Abstract
Heterosynaptic long-term depression (hetLTD) at one input can be induc ed by applying a conditioning stimulus to an adjacent set of synapses. In hippocampal CA1 pyramidal cells, our results suggest that hetLTD i s triggered by an extracellular diffusible factor that is released fol lowing tetanic activation of NMDA receptors. This hetLTD occludes with homosynaptic LTD suggesting common underlying mechanisms.