SYNTHESIS AND BIOLOGICAL EVALUATION OF ANTIPLATELET 2-AMINOCHROMONES

The synthesis and biological evaluation of a series of antiplatelet 2- morpholinylchromones has been described. Modification of the C-7 pheny lmethoxy group of ylmethoxy)-2-(4-morpholinyl)-4H-1-benzopyran-4-one ( 2) has led to the discovery of a series of 7-[(amino-ethyl)oxy]-8-meth yl derivatives which are potent inhibitors of ADP-induced platelet agg regation. Several members of this class proved active in preventing pl atelet-dependent thrombus formation in the dog, including yl)ethoxy]-2 -(4-morpholinyl)-4H-1-benzopyran-4-one (39) which was devoid of hemody namic effects at the effective antithrombotic dose.