CHARACTERIZATION OF ANTACID COMPOUNDS CONTAINING BOTH ALUMINUM AND MAGNESIUM .2. CODRIED POWDERS

The composition and antacid properties of six samples of codried antac ids containing both aluminum and magnesium were determined. Aluminum h ydroxide-magnesium carbonate codried gel and aluminum hydroxide-magnes ium hydroxide codried gel were nonhomogeneous, as the samples containe d combinations of hydrotalcite, amorphous aluminum hydroxide, magnesiu m hydroxide, magnesium hydroxycarbonate, and magnesium carbonate. All samples passed the preliminary antacid test and had high acid neutrali zing capacities. However, the rate of acid neutralization varied betwe en samples. In some cases the rate of acid neutralization at a dose of 400 mg was too slow to raise the pH to 3.0 as required by the Rossett -Rice test.