The effects of process and storage conditions of solid-state emulsions
were studied. Oil-in-water emulsions may be prepared from solid state
emulsions by adding an aqueous phase to the solid. Solid-state emulsi
ons are prepared by processing an oil phase and an aqueous solution of
matrix material via a solvent removal process. Sucrose, the carrier m
aterial utilized in this report, results in a metastable solid or glas
s, which can transform upon aging to a more stable thermodynamic state
. Aging was determined by monitoring the crystallinity as a function o
f time, temperature, relative humidity, and grinding. The crystallinit
y of solid-state emulsions was determined with X-ray diffraction and d
ifferential scanning calorimetry. Results indicate that solid-state em
ulsions should be stored between 15 and 25% relative humidity at 25-de
grees-C. Grinding has no apparent effect on the crystallinity of the s
ample, as detected by X-ray diffraction, although the microcrystallini
ty is increased. The utilization of silinized glassware enabled the sa
mple-to-sample microcrystalline variability to be reduced.