SOLID-STATE EMULSIONS - THE EFFECTS OF PROCESS AND STORAGE-CONDITIONS

The effects of process and storage conditions of solid-state emulsions were studied. Oil-in-water emulsions may be prepared from solid state emulsions by adding an aqueous phase to the solid. Solid-state emulsi ons are prepared by processing an oil phase and an aqueous solution of matrix material via a solvent removal process. Sucrose, the carrier m aterial utilized in this report, results in a metastable solid or glas s, which can transform upon aging to a more stable thermodynamic state . Aging was determined by monitoring the crystallinity as a function o f time, temperature, relative humidity, and grinding. The crystallinit y of solid-state emulsions was determined with X-ray diffraction and d ifferential scanning calorimetry. Results indicate that solid-state em ulsions should be stored between 15 and 25% relative humidity at 25-de grees-C. Grinding has no apparent effect on the crystallinity of the s ample, as detected by X-ray diffraction, although the microcrystallini ty is increased. The utilization of silinized glassware enabled the sa mple-to-sample microcrystalline variability to be reduced.