F. Versaci et al., A COMPARISON OF CORONARY-ARTERY STENTING WITH ANGIOPLASTY FOR ISOLATED STENOSIS OF THE PROXIMAL LEFT ANTERIOR DESCENDING CORONARY-ARTERY, The New England journal of medicine, 336(12), 1997, pp. 817-822
Background Randomized studies have shown that the use of coronary-arte
ry stenting as the initial treatment for coronary stenosis is associat
ed with a lower risk of restenosis than is standard coronary angioplas
ty. We prospectively investigated the efficacy of these two approaches
in selected patients with isolated stenosis of the proximal left ante
rior descending coronary artery. Methods A total of 120 patients with
isolated stenosis of the proximal left anterior descending coronary ar
tery were randomly assigned to stent implantation or standard coronary
angioplasty. The primary clinical end points were the rate of procedu
ral success (defined as residual stenosis of less than 50 percent and
the absence of death, myocardial infarction, and the need for coronary
-artery bypass surgery during the hospital stay) and the rate of event
-free survival (defined as freedom from death, myocardial infarction,
and the recurrence of angina) at 12 months. The angiographic end point
was the rate of restenosis 12 months after the procedure. Results The
two treatment groups did not differ significantly with respect to dem
ographic, clinical, or angiographic characteristics. The rates of proc
edural success were similar in the two groups of patients (95 percent
in the stenting group vs. 93 percent in the angioplasty group, P = 0.9
8). The 12-month rates of event-free survival were 87 percent after st
enting and 70 percent after angioplasty (P = 0.04). The rates of reste
nosis were 19 percent after stent implantation and 40 percent after an
gioplasty (P = 0.02). Conclusions In patients with symptomatic isolate
d stenosis of the proximal left anterior descending coronary artery, s
tenting had advantages over standard coronary angioplasty in that it w
as associated with both a lower rate of restenosis and a better clinic
al outcome. (C) 1997, Massachusetts Medical Society.