ALPHA-2,6-SIALYLTRANSFERASE PREDOMINATES IN CULTURED JEJUNUM OF SUCKLING RATS - IT IS UP-REGULATED BY DEXAMETHASONE AND SECRETED DURING CULTIVATION

Authors
HAMR A VLASAKOVA V KOLINSKA J
Citation
A. Hamr et al., ALPHA-2,6-SIALYLTRANSFERASE PREDOMINATES IN CULTURED JEJUNUM OF SUCKLING RATS - IT IS UP-REGULATED BY DEXAMETHASONE AND SECRETED DURING CULTIVATION, Biochimica et biophysica acta, 1157(3), 1993, pp. 285-289
Citations number
24
Categorie Soggetti
Biophysics,Biology
Journal title
Biochimica et biophysica acta → ACNP
ISSN journal
00063002
Volume
1157
Issue
3
Year of publication
1993
Pages
285 - 289
Database
ISI
SICI code
0006-3002(1993)1157:3<285:APICJO>2.0.ZU;2-X
Abstract
The alpha2,6-sialyltransferase (alpha2,6-ST) acting on N-acetyllactosa mine is the major sialyltransferase of suckling rat jejunum. Jejunal e xplants of 7-day-old rats maintained in serum-free or serum-containing organ culture secreted alpha2,6-ST into the cultivation medium. Dexam ethasone (80 nM) stimulates primarily the secreted pool of alpha2,6-ST . Fetal calf serum promotes the stimulatory effect of dexamethasone al so on the bound form of alpha2,6-ST.