FORMULATION FACTORS AFFECTING THIMEROSAL STABILITY

Authors
RABASCO AM CARABALLO I FERNANDEZAREVALO M
Citation
Am. Rabasco et al., FORMULATION FACTORS AFFECTING THIMEROSAL STABILITY, Drug development and industrial pharmacy, 19(14), 1993, pp. 1673-1691
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Drug development and industrial pharmacy → ACNP
ISSN journal
03639045
Volume
19
Issue
14
Year of publication
1993
Pages
1673 - 1691
Database
ISI
SICI code
0363-9045(1993)19:14<1673:FFATS>2.0.ZU;2-T
Abstract
A high-performance liquid chromatographic (HPLC) assay has been develo ped for thimerosal and some of its degradation products: thiosalicylic and 2,2'-dithiosalicylic acids. Using this method, the influence of f ormulation factors as: isotonic agent, initial concentration, addition of tromethamine, pH and container material, over thimerosal stability was studied.