THE DEVELOPMENT OF DNA PROFILING DATABASE IN AN HAE-III BASED RFLP SYSTEM FOR CHINESE, MALAYS, AND INDIANS IN SINGAPORE

Deoxyribonucleic acid (DNA) restriction fragment length polymorphism ( RFLP) profiles were obtained for blood specimens from the three popula tion groups-Chinese, Malays and Indians-in Singapore. The population d atabases were collected from Hae III digested high molecular weight DN A hybridized with four variable number of tandem repeats (VNTR) loci - D2S44, D10S28, D4S139 and D1S7. The data were analyzed statistically using the fixed bin system. Comparison of ratio of bin frequencies of these population data with published data on whites, blacks, and hispa nics shows that the alleleic distribution at these loci is not serious ly different among the six groups. This has important implications to the statistical significance of forensic DNA applications.