MODIFICATION OF POLYMERS WITH BIOLOGICALL Y-ACTIVE COMPOUNDS

The paper gives a survey of the methods, used for preparation of multi component catalytical systems, that involve conventional chemical modi fication of polymers by biologically active compounds or copolymerizat ion of the corresponding macromonomers with hydrophilic monomers. Usin g the enzyme-cofactor system and mixtures of enzymes (protease-heparin , protease-hydrocarbon radical, serum albumin-oxyreductase, etc.) as e xamples we show that the occurrence of consecutive catalytical reactio ns is possible only when the arrangement of the immobilized compounds in the bulk of the polymer or at its surface is favorable. Polymer mod ification using copolymerization is shown to be the procedure that bes t conforms to this requirement. The prospects of using multicomponent systems to control enzyme specificity, create blood compatible polymer ic materials, and enhance the efficaciousness/efficiency of biospecifi c sorbents are demonstrated.