PHARMACOKINETICS OF INTRAMUSCULARLY ADMINISTERED ISEPAMICIN IN MAN

The pharmacokinetics of isepamicin, a broad-spectrum aminoglycoside an tibiotic, was studied in man after intramuscular administration. Two g roups each of 6 volunteers received isepamicin for 10 consecutive days by intramuscular injection at respective doses of 7.5 mg/kg once dail y or 7.5 mg/kg twice daily. Plasma and urinary concentrations of isepa micin were determined using a specific HPLC method. In both groups, th ere was no drug accumulation following multiple administration. The t( 1/2), which ranged from 2.4 to 2.7 h, was independent of the dosage re gimen. Isepamicin excreted into (0-24 h) urine accounted for virtually 100% of the dose. The results show that the pharmacokinetics of isepa micin are similar with these dosage regimens. The drug undergoes no de tectable biotransformation, does not accumulate upon multiple dosing, and is cleared solely by urinary excretion.