OUTER-MEMBRANE PROTEINS AND ELASTASE OF PSEUDOMONAS-AERUGINOSA AFTER THE POSTANTIBIOTIC EFFECT INDUCED BY AMIKACIN

Postantibiotic effects were induced in three Pseudomonas aeruginosa st rains after short-term treatment (30 min) with amikacin at suprainhibi tory concentrations in the range of 0.6-1.2 h (2 x MIC) and of 3.0-4.4 h (4 x MIC). Significant suppression of P. aeruginosa elastase activi ty was found after treatment with amikacin at 4 x MIC concentration (t o 10-69.2% of the control values); 2 x MIC was less effective. The pro file of outer membrane proteins of P. aeruginosa was not changed after treatment with amikacin at both concentrations.