INTERACTION BETWEEN THIAMINETETRAHYDROFURFURYL DISULFIDE WITH FATTY-ACID IN 1,2-DICHLOROETHANE

The interaction between thiamine tetrahydrofurfuryl disulfide (TTFD) a nd saturated fatty acid (FA) in 1,2-dichloroethane at 25-degrees-C was studied by phase solubility analysis using FA with various carbon num bers (14, 16. and 18), stearyl alcohol, and stearic acid methyl ester. The solubility of (TTFD) increased with the addition of FA. The solub ility of TTFD also increased with the addition of stearyl alcohol, whi le its solubility decreased when stearic acid methyl ester was added. It was found that the solubility of stearic acid also increased with t he addition of TTFD, and that TTFD cannot form a crystalline complex w ith stearic acid. These results are compared with those obtained for t hiamine disulfide (TDS) and cycotiamine. The mode of the solubilizatio n of TDS by FA in 1,2-dichloroethane, and its relation to the crystall ization of the complex between TDS and FA was discussed.