SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 7-SUBSTITUTED PROCATEROL DERIVATIVES

Authors
YOSHIZAKI S TAMADA S YO E UMEZATO M
Citation
S. Yoshizaki et al., SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 7-SUBSTITUTED PROCATEROL DERIVATIVES, Chemical and Pharmaceutical Bulletin, 41(7), 1993, pp. 1305-1306
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
41
Issue
7
Year of publication
1993
Pages
1305 - 1306
Database
ISI
SICI code
0009-2363(1993)41:7<1305:SAPEO7>2.0.ZU;2-#
Abstract
A series of procaterol derivatives having a substituent at the 7-posit ion of the carbostyril moiety was synthesized. Halogenation of procate rol and its homologues gave the 7-halogeno derivatives (3). Nitration of the procaterol analogues afforded the 7-nitro derivatives (4), and the catalytic reduction of 4 gave the 7-amino derivatives (5). These c ompounds showed weak beta-adrenoceptor stimulant activities in anesthe tized dog.