LYMPHOCYTIC MENINGITIS FOLLOWING INSERTION OF A PORCINE DERMIS DURAL GRAFT

We describe a case of lymphocytic meningitis following insertion of a porcine dermis implant to repair an operative dural defect. Histology of the excised implant revealed local abscess formation with a granulo matous reaction. Oligoclonal Immunoglobulin G, part of which could be removed by absorption with the porcine dermis, was present in the pati ent's cerebrospinal fluid, and, to a less marked degree, in his serum. The cerebrospinal fluid glucose was markedly depressed. An unusual hy persensitivity reaction to the porcine implant was considered the most likely explanation for this meningitic illness. The patient went on t o make a full recovery following excision of the implant.