ENDOSCOPIC AND PH-METRIC STUDY OF PROTECT IVE AND ANTACID ACTIVITY OFALUMINUM PHOSPHATE IN ANESTHETIZED DOG

The pharmacological activity of a new patent medicine containing alumi nium phosphate (Phosphaluvet (R), 1 ml.kg-1) has been blindly measured , versus a gelatin placebo, in vivo in anesthetized dog. The surface o f coated mucosa and the protection against ethanol-induced (4 ml.kg-1) lesions were endoscopically quantified and were significantly greater with aluminium phosphate. The antacid activity was measured during a 45 minutes intragastric pH record after pentagastrin stimulation (6 mu g.kg- 1), and showed a significant increase of mean pH from the 15th t o the 45th minute (2,09 +/- 0,15 vs 1,02 +/- 0,18), of mean acid activ ity (13,3 mEq.l-1 vs 131,2), and a lower fraction of recording time at pH below 1 (4,6 +/- 2,5 vs 57,1 +/- 9,2) and below 2 (49,6 +/- 5,3 ce ntre 78,8 +/- 7,1). These results suggest a very good gastric mucosal protection of aluminium phosphate in the dog, due to a high coating pr operty, a bufer antacid activity, and probably a cytoprotective action .