The technique of 20-MHz B-scan sonography is non-invasive and allows q
uantification of the different compartments of the skin. Seven patient
s with atrophic linear circumscribed scleroderma and one patient with
guttate circumscribed scleroderma were examined by ultrasound. All pat
ients were found to have a total or subtotal loss of subcutaneous fatt
y tissue, whereas the thickness of the dermis remained almost unchange
d. These findings should lead to further investigation of the pathophy
siological mechanism involved in subcutaneous atrophy in circumscribed
scleroderma.