DISCOID LUPUS-ERYTHEMATOSUS - LIKE SKIN-L ESIONS IN A CARRIER OF CHRONIC GRANULOMATOUS-DISEASE

We present a clinically atypical case of discoid lupus erythematosus i n the mother of a boy with chronic granulomatous disease. In this diso rder, the phagocytes are unable to produce superoxide anion to degrade incorporated microorganisms. In addition to a discoid lupus erythemat osus-like skin disease, recurrent stomatitis aphthosa, hidradenitis su ppurativa and Raynaud phenomenon are markedly associated with heterozy gote carriers of chronic granulomatous disease. Based on this conspicu ous association, diverse models concerning the pathogenesis of lupus e rythematosus are discussed.