The final diagnosis of granulomatous gastritis is based on morphologic
al findings and clinical and laboratory data. Detailed analysis of the
morphological features of the granulomas together with associated muc
osal changes could generate more information on aetiology and pathogen
esis. Biopsies from 71 patients diagnosed as having granulomatous gast
ritis were reviewed. Thirty-seven of these patients (52%) had Crohn's
disease. In 18 patients (25%) an isolated granulomatous gastritis was
diagnosed. In seven patients (10%) the final diagnosis was a foreign b
ody reaction. Of the remaining cases, four (7%) corresponded to tumour
-associated granulomas and one case each of sarcoidosis (1%), Whipple'
s disease (1%) and vasculitis-associated disease (1%). Two cases (3%)
were unclassifiable. The granulomas were mainly found in the antrum (6
4% antrum only, 11% antrum and corpus, 6% transitional mucosa corpus-a
ntrum). Granulomas were usually small. This was particularly true for
those found in patients with Crohn's disease. Multiple granulomas were
observed in the sarcoidosis, the Whipple's disease and vasculitis-ass
ociated cases. A pattern of chronic gastritis with atrophy was present
in 95% of the biopsies (68/71 patients). Helicobacter pylori was dete
cted in 92% of the biopsies (64/71 patients).