KINETIC-STUDY OF N-BROMOSUCCINIMIDE REACTIONS AND KINETIC DETERMINATION OF PYRIDOXINE USING A BROMIDE-SELECTIVE ELECTRODE

The bromide released by the alkaline hydrolysis of N-bromosuccinimide and its reactions with bromide, pyridoxine and thiamine have been stud ied potentiometrically using a solid-state bromide-selective electrode to monitor the consumed or produced bromide ion. Potential-time indic ations are obtained using a microcomputer-controlled potentiometric sy stem. The overall rate constants and the activation energies have been calculated. A kinetic-potentiometric procedure for the determination of pyridoxine in the presence of thiamine in pharmaceutical preparatio ns, based on its reaction with N-bromosuccinimide, is presented.