REACTION OF ORGANOLEAD TRIACETATES WITH HOXYCARBONYL-2-METHYL-4,5-DIHYDRO-1,3-OXAZOL-5-ONE - THE SYNTHESIS OF ALPHA-ARYL-N-ACETYLGLYCINES AND ALPHA-VINYL-N-ACETYLGLYCINES AND THEIR ETHYL-ESTERS AND THEIR ENZYMATIC RESOLUTION

hoxycarbonyl-2-methyl-4,5-dihydro-1,3-oxazol-5-one 7, which may be rea dily obtained from diethyl acetamidomalonate, undergoes high-yielding arylation and vinylation at the 4-position with organolead triacetates to give compounds which may be hydrolysed to give either the alpha-ar yl-or alpha-vinyl-N-acetylglycine or the corresponding ethyl ester. Th e kinetic resolution of a number of these derivatives by enzymic hydro lysis of either the amide or ester function has been demonstrated.