POSTPARTUM CEREBRAL INFARCTION ASSOCIATED WITH ASPIRIN WITHDRAWAL IN THE ANTIPHOSPHOLIPID ANTIBODY SYNDROME

We observed 2 cases of antiphospholipid syndrome complicated with hemi paresis appearing after delivery. During pregnancy, both women were sy stematically treated with aspirin (100 mg/day) in addition to predniso ne in the second case. Cerebral infarction appeared a few hours after delivery and 8 days after discontinuation of aspirin. The close tempor al relationship between discontinuation of aspirin and stroke occurrin g in early postpartum period suggests a causal link. If aspirin must b e stopped for obstetrical reasons, we think that efficient anticoagula tion should be started even if the presence of the antiphospholipid an tibodies has been priorly asymptomatic.