GENITOURINARY MALACOPLAKIA

Between 1973 and 1991, 13 patients with malakoplakia (MKP) have been d iagnosed and treated. The lesions involved all sites in the genitourin ary tract; 2 patients had multiple and 11 had single lesions. Treatmen t was based on 2 criteria: (a) pharmacological treatment with trimetho prim-sulphamethoxazole and/or ascorbic acid and/or bethanechol chlorid e; (b) excision of the MKP lesion either endoscopically or by open sur gery. Two patients died (1 from multiple MKP and the other from a myoc ardial infarct); the remainder did well. The pathogenic, diagnostic an d therapeutic aspects of the disease are discussed.