We report 2 patients with DIDMOAD syndrome (diabetes insipidus, diabet
es mellitus, optic atrophy and neural deafness), with emphasis on the
urological aspects and their management. Both patients underwent thoro
ugh radiological endoscopic and urodynamic evaluation, in addition to
detailed evaluation of other systems involved. Each had the characteri
stic hyper-reflexive neurogenic bladder with sphincteric dyssynergia,
which resulted in severe urinary tract dilation. One patient was diagn
osed at this institution and managed conservatively with clean intermi
ttent catheterisation and anticholinergic medication; the second patie
nt was referred to us after several attempts at surgical correction. T
he presentation, details of the urological evaluation with special emp
hasis on the urodynamic findings, and the outcome of different means o
f management are discussed.