Objective The authors prospectively studied the impact of immediate br
east reconstruction on patients undergoing mastectomy. Summary Backgro
und Data Despite the advocation of a breast-conserving approach to the
treatment of breast cancer, many women continue to medically require
or choose mastectomy for the treatment of breast cancer. In recent yea
rs, immediate breast reconstruction has become an alternative to eithe
r mastectomy alone or to delayed reconstruction. Methods A prospective
database of 216 patients who underwent mastectomy with immediate reco
nstruction was established. In this series, 94 procedures involved imp
lants or tissue expanders, and 124 tissue transfers were performed. Re
sults The overall complication rate was 15.3%; only 9% of patients who
underwent autologous tissue transfers required secondary procedures.
When implants were performed, the overall rate of prosthetic loss was
8%. The majority of patients (n = 101) underwent transverse rectus abd
ominis musculocutaneous (TRAM) flaps. Twenty-six of the 38 (17.5%) pat
ients who required transfusion were from this group. Partial flap loss
es in this group (7%) were correlated to a history of heavy smoking. W
ith a median follow-up of 33.2 months, only two patients had recurred
locally. According to patient opinion, autologous tissue transfers res
ulted in a statistically better cosmetic result. Conclusions Immediate
reconstruction can be performed safely and with excellent cosmetic re
sults.