PLASMA CYTOKINES AFTER THERMAL-INJURY AND THEIR RELATIONSHIP TO INFECTION

Objective The relationship of plasma cytokine levels to infection, cor e temperature, and to one another in patients with thermal injury was examined. Summary Background Data The response to infection has been a ssociated with cytokines such as interleukin 1beta (IL1beta), interleu kin 6 (IL6), and tumor necrosis factor alpha (TNFalpha), and these cyt okines have been studied in various inflammatory diseases. The authors previously reported that patients with thermal injury have elevated I L1beta and IL6 plasma levels and that these cytokines may play differe nt roles in the response to thermal injury. Methods IL1beta, IL6, and TNFalpha were measured by enzyme-linked immunosorbent assay (ELISA) in serial samples of plasma from 27 patients. Results IL6 and TNFalpha l evels were increased in severely infected patients as compared to pati ents who remained free of infection, and the IL6 level was higher in i nfected patients who died than those who survived. There was no appare nt relationship between IL1beta levels and infection. IL6 and IL1beta were positively correlated with core temperature. The correlations bet ween IL6 and IL1beta, between IL6 and TNFalpha, and between TNFalpha a nd IL1beta were significant. Conclusions These results suggest that IL 6 and TNFalpha play a role in the response of burned patients to infec tion.