In evaluating recurrent childhood infections, the physician must keep
in mind the rarity of true immunodeficiency and the frequency of atopy
, day care, exposure to cigarette smoke and anatomic variations as pre
disposing factors in recurrent childhood illnesses. Determining true i
mmunodeficiency involves exclusion of risk factors for human immunodef
iciency virus infection, identification of a family history of immunod
eficiency and recognition of specific physical and laboratory findings
. in most cases, screening immunoglobulin studies will distinguish the
normal child from the child with an abnormal immune system. Managemen
t of the patient with true immunodeficiency is carried out in collabor
ation with specialists in these uncommon disorders.